Then add on ancient writings from very early civilizations and advanced technology that can't be explained away by gene mutations, you have a definite gap occurring between the old science thinkers and the emerging new plasma, soft physics group that are breaking ground practically every day in fields and questions like "Dark Matter" indicating and behaving intelligently.
Or the Cern Accelerator experiments as well as those of human communication with its own DNA as well as Dark Matters communication with our DNA. That one blew me away. I put this here because we are evolving rapidly, and that means our power is increasing exponentially. Have you interacted with a new baby lately, at say, about 2 months old? They are amazingly old souls with the ability to focus and act like they recognize you and they react accordingly. I was around when that was just unheard of. Babies in my day were totally reactive to the stimulus in their environment and did not focus or concentrate on one object.
Today, they ignore mostly, stimulus from their environments and focus most intently on any new face they see, which is an anomoly..... then notice the purity of their spirits and it explains why Jesus mentions children in the NT over 23 times. And how he says that if you harm one of these, it would be better that you had a rock tied around your neck and thrown into the sea, than to face the penalty for harming one of those little ones. I suspect our satanic leaders do not have a very pleasant future ahead of them... given the harm they have done to our children. As usual, you read and decide. definitely check things out for yourself and make up your own mind, but I believe this is the way out for all of us if we work together to do it.
Human Evolution Enters an Exciting New Phase
http://www.wired.com/wiredscience/2012/11/recent-human-evolution-2By Brandon Keim, Wired - science
11.29.12
In the most massive study of genetic variation yet, researchers estimated the age of more than one million variants, or changes to our DNA code, found across human populations. The vast majority proved to be quite young. The chronologies tell a story of evolutionary dynamics in recent human history, a period characterized by both narrow reproductive bottlenecks and sudden, enormous population growth.
The evolutionary dynamics of these features resulted in a flood of new genetic variation, accumulating so fast that natural selection hasn’t caught up yet. As a species, we are freshly bursting with the raw material of evolution.
“Most of the mutations that we found arose in the last 200 generations or so. There hasn’t been much time for random change or deterministic change through natural selection,” said geneticist Joshua Akey of the University of Washington, co-author of the Nov. 28 Nature study. “We have a repository of all this new variation for humanity to use as a substrate. In a way, we’re more evolvable now than at any time in our history.”
Akey specializes in what’s known as rare variation, or changes in DNA that are found in perhaps one in 100 people, or even fewer. For practical reasons, rare variants have only been studied in earnest for the last several years. Before then, it was simply too expensive. Genomics focused mostly on what are known as common variants.
However, as dramatically illustrated by a landmark series of papers to appear this year — by Alon Keinan and Andrew Clark, by Matt Nelson and John Novembre, and another by Akey’s group, all appearing in Science, along with new results from the humanity-spanning 1,000 Genomes Project — common variants are just a small part of the big picture. They’re vastly outnumbered by rare variants, and tend to have weaker effects.
The medical implications of this realization are profound. The previously unappreciated significance of rare variation could explain much of why scientists have struggled to identify more than a small fraction of the genetic components of common, complex disease, limiting the predictive value of genomics.
'The genetic potential of our population is vastly different than what it was 10,000 years ago.'
But these findings can also been seen from another angle. They teach us about human evolution, in particular the course it’s taken since modern Homo sapiens migrated out of Africa, learned to farm, and became the planet’s dominant life form.
“We’ve gone from several hundred million people to seven billion in a blink of evolutionary time,” said Akey. “That’s had a profound effect on structuring the variation present in our species.”
Akey isn’t the first scientist to use modern genetic data as a window into recent and ongoing human evolution, nor the first to root rare variation in humanity’s post-Ice Age population boom. The new study’s insights reside in its depth and detail.
The researchers sequenced in exhaustive detail protein-coding genes from 6,515 people, compiling a list of every DNA variation they found — 1,146,401 in all, of which 73 percent were rare. To these they applied a type of statistical analysis, customized for human populations but better known from studies of animal evolution, that infers ancestral relationships from existing genetic patterns.
“There were other hints of what’s going on, but nobody has studied such a massive number of coding regions from such a high number of individuals,” said geneticist Sarah Tishkoff of the University of Pennsylvania.
Akey’s group found that rare variations tended to be relatively new, with some 73 percent of all genetic variation arising in just the last 5,000 years. Of variations that seem likely to cause harm, a full 91 percent emerged in this time.
Why is this? Much of it is a function of population growth. Part of it is straightforward population growth. Just 10,000 years ago, at the end of the last Ice Age, there were roughly 5 million humans on Earth. Now there are 7 billion. With each instance of reproduction, a few random variations emerge; multiply that across humanity’s expanding numbers, and enormous amounts of variation are generated.
Also playing a role are the dynamics of bottlenecks, or periods when populations are reduced to a small number. The out-of-Africa migration represents one such bottleneck, and others have occurred during times of geographic and cultural isolation. Scientists have shown that when populations are small, natural selection actually becomes weaker, and the effects of randomness grow more powerful.
Put these dynamics together, and the Homo sapiens narrative that emerges is one in which, for non-African populations, the out-of-Africa bottleneck created a period in which natural selection’s effects diminished, followed by a global population boom and its attendant wave of new variation.
The result, calculated Akey, is that people of European descent have five times as many gene variants as they would if population growth had been slow and steady. People of African descent, whose ancestors didn’t go through that original bottleneck, have somewhat less new variation, but it’s still a large amount: three times more variation than would have accumulated under slow-growth conditions.
Natural selection never stopped acting, of course. New mutations with especially beneficial effects, such as lactose tolerance, still spread rapidly, while those with immediately harmful consequences likely vanished within a few generations of appearing. But most variation has small, subtle effects.
Visualization of the distribution of potentially harmful genetic variation across protein-coding portions of the human genome. The top section represents variation that predates the human population explosion 10,000 years ago. The bottom represents variation that arose since then. Image: Fu et al./Nature
It’s this type of variation that’s proliferated so wildly. “Population growth is happening so fast that selection is having a hard time keeping up with the new, deleterious alleles,” said Akey.
One consequence of this is the accumulation in humanity of gene variants with potentially harmful effects. Akey’s group found that a full 86 percent of variants that look as though they might be deleterious are less than 10,000 years old, and many have only existed for the last millennium.
“Humans today carry a much larger load of deleterious variants than our species carried just prior to its massive expansion just a couple hundred generations ago,” said population geneticist Alon Keinan of Cornell University, whose own work helped link rare variation patterns to the population boom.
The inverse is also true. Present-day humanity also carries a much larger load of potentially positive variation, not to mention variation with no appreciable consequences at all. These variations, known to scientists as “cryptic,” that might actually be evolution’s hidden fuel: mutations that on their own have no significance can combine to produce unexpected, powerful effects.
Indeed, the genetic seeds of exceptional traits, such as endurance or strength or innate intelligence, may now be circulating in humanity. “The genetic potential of our population is vastly different than what it was 10,000 years ago,” Akey said.
How will humanity evolve in the next few thousand years? It’s impossible to predict but fun to speculate, said Akey. A potentially interesting wrinkle to the human story is that, while bottlenecks reduce selection pressure, evolutionary models show that large populations actually increase selection’s effects.
Given the incredible speed and scope of human population growth, this increased pressure hasn’t yet caught up to the burst of new variation, but eventually it might. It could even be anticipated, at least from theoretical models, that natural selection on humans will actually become stronger than it’s ever been.
“The size of a population determines how much selection is going to be acting moving forward,” said anthropologist Mark Shriver of Penn State University. “You have an increase in natural selection now.”
An inevitably complicating factor is that natural selection isn’t as natural as it used to be. Theoretical models don’t account for culture and technology, two forces with profound influences. Widespread use of reproductive technologies like fetal genome sequencing might ease selection pressures, or even make them more intense.
As for future studies in genetic anthropology, Akey said scientists are approaching the limits of what can be known from genes alone. “We need to take advantage of what people have learned in anthropology and ecology and linguistics, and synthesize all this into a coherent narrative of human evolution,” he said.
Geneticist Robert Moyzis of the University of California, Irvine, co-author of a 2007 study on accelerating human evolution, noted that the new study only looked at protein-coding genes, which account for only a small portion of the entire human genome. Much of humanity’s rare variation remains to be analyzed.
Moyzis’ co-authors on that study, geneticist Henry Harpending of the University of Utah and anthropologist John Hawks of the University of Wisconsin, also warned against jumping to early conclusions based on the new study’s dating. Some of what appears to be new variation might actually be old, said Hawks.
Even with these caveats, however, the study’s essential message is unchanged. “Sometimes people ask the question, ‘Is human evolution still occurring?’” said Tishkoff. “Yes, human evolution can still occur, and it is.”
Citations: “Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants.” By Wenqing Fu, Timothy D. O’Connor, Goo Jun, Hyun Min Kang, Goncalo Abecasis, Suzanne M. Leal, Stacey Gabriel, David Altshuler, Jay Shendure, Deborah A. Nickerson, Michael J. Bamshad, NHLBI Exome Sequencing Project & Joshua M. Akey. Vol. 491, No. 7426, Nov. 29, 2012
The article is reproduced in accordance with Section 107 of title 17 of the Copyright Law of the United States relating to fair-use and is for the purposes of criticism, comment, news reporting, teaching, scholarship, and research.
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